Mental Stress The standard protocol for mental stress is the prescription of selective serotonin re-uptake inhibitors (SSRIs) also known as anti-depressants. Does Brain Training Therapy Work? These work to stimulate the production of serotonin- the “feel good” neurotransmitter. Short-term, these are effective in helping a patient “feel good” but they don’t actually correct the problem. Medications can have their place in the short term, but they do not address the underlying brainwave abnormality. How Can Neurofeedback help Neurofeedback is actually a learning modality designed to retrain abnormal brainwave patterns and is shown to normalize brainwaves.